Product #: PTX-002S anti-Fx1A Serum
Sheep
Anti-Fx1A Serum
For the Induction of Accelerated Passive Heymann
(membranous) Nephritis
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Directions For Use:
This package contains sufficient antibody to induce disease in at least
25 rats when used according to the instructions below. Please read carefully
before starting the procedure.
Injection of anti-Fx1A
serum:
Anesthetize
rats and inject 0.5 ml/100 gm body weight of anti-Fx1A antibody into a tail vein over a
15
second period (Larger volumes are required for heavier rats). Production
of disease is dose dependent. For more disease inject more volume of antibody.
Doses over 1.5 ml/rat are not recommended. It is important that the complete
dose of antibody is delivered. If the investigator is not experienced
with tail vein injections, we recommended a number of practice injections
of saline in sham rats before going forward antibody experiments. Disease
will be noticeable within 2 weeks by increased proteinuria and histological
alterations in glomerular structures.
1. Salant DJ, Cybulsky
AV: Experimental glomerulonephritis. Meth Enzymol 162:421-461, 1988.
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