Product #: PTX-001S anti-GBM Serum
Sheep Anti-Rat Glomeruli (GBM) Serum
For the Introduction of Passive Anti-GBM Nephritis
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Directions For Use:
This package contains sufficient antisera to induce disease in at least
25 rats when used according to the instructions below. Please read carefully
before starting the procedure.
Injection of anti-GBM serum: Anesthetize rat(s). Inject .4 ml/100 gm body weight of anti-GBM serum into a tail vein as a bolus over a 15 second period (Larger volumes are required for heavier rats). Allow the rat to recover and return to cage. Production of disease is dose dependent. For a more fulminant disease inject more volume of antibody. Doses over 1.5 ml/rat are not recommended. It is important that the complete dose of antibody is delivered iv. If the investigator is not experienced with tail vein injections, we recommended a number of practice injections in sham rats before going forward antibody experiments.
1. Salant DJ, Cybulsky
AV: Experimental glomerulonephritis. Meth Enzymol 162:421-461, 1988.
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