Description of Renal Disease PTX-003

Product #: PTX-003 ATS-IgG antibody

Sheep Anti-Rat Thymocyte (Thy-1) IgG

For the Introduction of Mesangial Proliferative Glomerulonephritis

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Description of Renal Disease:

Mesangiolysis occurs shortly after injection of antibody (1). Mesangioproliferative lesions begin 4-7 days after injection (1). Lesions resolve within several weeks after injection of antibody. A progressive glomerulosclerosis and fibrosis can be induced by multiple injections of ATS IgG several days apart (1,2)*. Apoptosis has also been observed early (3,4) and late (5) in the progression of anti-Thy-1 nephritis providing a model to study mechanisms of programmed cell death in renal disease.*

Glomerulus 5 days after injection of ATS IgG showing mesangial proliferative lesions.

*Reported in the literature, but Probetex has not tested the product for this application.

1. Yamamoto T. Wilson CB. Kidney International. 32:514-25,1987

2. Yamamoto T. Noble NA. Miller DE. Border WA. Kidney International. 45:916-27, 1994

3. Bagchus WM. Jeunink MF. Elema JD. American Journal of Pathology. 137:215-23, 1990

4. Shimizu A. Kitamura H. Masuda Y. Ishizaki M. Sugisaki Y. Yamanaka N. Kidney International. 47:114-21, 1995

5. Baker AJ. Mooney A. Hughs J. Lombardi D. Johnson RJ. Savill J. Journal of Clinical Investigation. 94:2105-16,1994

Materials | Directions For Use | Description of Renal Disease | Download Full Data Sheet